About Us
The Bortoluzzi laboratory works in the field of computational biomedicine, bioinformatics and AI applied mainly to cancer research.
The group has expertise in systems biology, big data and NGS for transcriptome and genome analysis and know-how regarding microRNAs, non-coding RNAs and circular RNA biology and bioinformatics. We also develop new methods, software and web tools.
We are engaged in a number of projects analyzing cancer cell genomic landscape and multi-omic data, in relation to the origin as well as disease evolution, with applications in precision medicine. One of our main goals is the definition of circular RNA roles in hematologic malignancies and their participation to disease mechanisms and to understand the biological factors underlying circRNAome dysregulation in cancer. We intensively work on the development of RNA-therapies and on the development of AI based models for patient stratification in relation to disease molecular subtypes and prognostication of cancer recurrence, aggressiveness and response to therapies.
