{"id":671,"date":"2025-09-25T12:22:39","date_gmt":"2025-09-25T10:22:39","guid":{"rendered":"https:\/\/compgen.bio.unipd.it\/new\/?page_id=671"},"modified":"2025-10-13T12:23:34","modified_gmt":"2025-10-13T10:23:34","slug":"cariparo","status":"publish","type":"page","link":"https:\/\/compgen.bio.unipd.it\/new\/projects\/cariparo\/","title":{"rendered":"Cariparo"},"content":{"rendered":"
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CARIPARO Excellence Project 2024-2026\n<\/h3><\/div><\/div><\/div><\/div>

Exploring bone marrow in T-LGL leukemia: the hive of activity addressing disease onset, progression and concurrent dysplasia unbalances<\/h3><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t
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\"Image\"<\/div>
WPPB Image Addons<\/figcaption><\/figure><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t <\/div>\n\n <\/div>\n <\/div>\n\t\t\t\t
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    \n
  • PI Prof. Renato Zambello (DIMED, UniPD)<\/li>\n
  • Dr. Antonella Teramo<\/li>\n
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    Dr. Giulia Calabretto<\/p>\n<\/li>\n

  • \n

    Dr. Elisa Rampazzo<\/p>\n<\/li>\n

  • \n

    Dr. Elena Buson<\/p>\n<\/li>\n

  • \n

    Dr. Valentina Trimarco<\/p>\n<\/li>\n<\/ul><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t

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    • Prof. Stefania Bortoluzzi (DISCOG, UniPD)<\/li>\n
    • Dr. Enrico Gaffo<\/li>\n
    • Dr. Ilias Glogovitis<\/li>\n
    • Dr. Silvia Orsi<\/li>\n<\/ul><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t
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      • Prof. Marco Pizzi (DIMED, UniPD)<\/li>\n
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        Dr. Vincenza Guzzardo<\/p>\n<\/li>\n

      • \n

        Dr. Federico Scarmozzino<\/p>\n<\/li>\n<\/ul><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t <\/div>\n\n <\/div>\n <\/div>\n\t\t\t\t

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        Short project description<\/h3><\/div><\/div><\/div><\/div>

        T-LGLL (large granular lymphocyte leukemia) is a chronic lymphoproliferative disorder presenting with cytopenias that are linked to impaired immune system and related morbidity. Recent studies showed bone marrow dysplastic alterations, in some T-LGLL cases, with a risk of progression to myelodysplastic syndromes (MDS). T-LGLL originates in the bone marrow (BM), where LGLs encounter potential triggering antigens, and where the processes leading to cytopenias and dysplastic alterations take place.<\/p>\n

        Our project aims to characterize the BM niche in T-LGLL compared to healthy controls, combining single-cell RNA sequencing (RNA-seq) on hematopoietic BM cells and spatial transcriptomic analysis plus multiplexed immunohistochemistry on BM biopsies.<\/strong><\/p>\n

        We are using cutting-edge technologies, in combination with bioinformatic and artificial intelligence approaches, to portray the features of the BM in unprecedented detail, ultimately translating into new therapeutic targets for T-LGLL and related disorders.<\/p><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t <\/div>\n\n <\/div>\n <\/div>\n\t\t\t\t

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        Publications<\/h3><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t
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        Congresses<\/h3><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t
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        Press releases<\/h3><\/div><\/div><\/div><\/div> <\/div>\n <\/div>\n <\/div>\n\t\t\t\t\t\t\t\t\t <\/div>\n\n <\/div>\n <\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

        CARIPARO Excellence Project 2024-2026 Exploring bone marrow in T-LGL leukemia: the hive of activity addressing disease onset, progression and concurrent dysplasia unbalances WPPB Image Addons PI Prof. Renato Zambello (DIMED, …<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":589,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-671","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/pages\/671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/comments?post=671"}],"version-history":[{"count":1,"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/pages\/671\/revisions"}],"predecessor-version":[{"id":672,"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/pages\/671\/revisions\/672"}],"up":[{"embeddable":true,"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/pages\/589"}],"wp:attachment":[{"href":"https:\/\/compgen.bio.unipd.it\/new\/wp-json\/wp\/v2\/media?parent=671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}