Gene/TF/miRNA LogFC PMFvsBM LogFC PMFvsPB
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PMF NETWORK MODEL

The network depicts a data-driven model of transcriptional and post-transcriptional alterations of primary myelofibrosis (PMF) CD34+ cells, in terms of genes, transcription factors (TF) miRNAs and connection thereof.

The networks derived from most deregulated pathways are linked to inferred mixed miRNA/TF/gene circuits, providing a global overview of transcriptional and post-transcriptional deregulations in PMF, unifying consolidated and predicted data.

A data-driven network model of PMF: transcriptional and post-transcriptional alterations in PMF CD34+ cells
Enrica Calura, Silvia Pizzini, Andrea Bisognin, Alessandro Coppe, Gabriele Sales, Enrico Gaffo, Tiziana Fanelli, Carmela Mannarelli, Roberta Zini, Ruggiero Norfo, Valentina Pennucci, Rossella Manfredini, Chiara Romualdi, Paola Guglielmelli, Alessandro Maria Vannucchi, Stefania Bortoluzzi.