Development of bioinformatics methods for circRNA charachterization 

Several project are ongoing aiming at the characterizing circular RNAs expression and role in normal hematopoiesis and in hematologic malignancies. Our goals are to disclose aberrantly expressed or fusion circRNAs of malignant cells, clarify their involvement in disease mechanisms and their usefulness ad biomarkers. The projects entails a combination of multi-omic profiling, bioinformatics analysis, and functional experiments.

Study of circRNA role in haematologic malignancies 

Several project are ongoing aiming at the characterizing circular RNAs expression and role in normal hematopoiesis and in hematologic malignancies. Our goals are to disclose aberrantly expressed or fusion circRNAs of malignant cells, clarify their involvement in disease mechanisms and their usefulness ad biomarkers. The projects entails a combination of multi-omic profiling, bioinformatics analysis, and functional experiments.

Analysis of genome sequencing data to study cancer genomics 

We develop informatics tools for analysis of genome sequencing data obtained from solid and blood cancers to prioritize variants, identify mutations driving cancer development and progression. Moreover, we use advanced systems genetics approaches to identify significantly mutated pathways and biological functions involved in cancer dynamics. 

We explore and reconstruct clonal evolution in leukemias tracking the mutational profile changes to disclose the biological features responsible for the relapse or the chemotherapy resistance in order to help the refinement of clinical treatments.